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After more than 20 years at the top of the daytime talk show game, Oprah Winfrey‘s calling it quits. Tim Bennett, president of Winfrey’s Harpo production house, announced that the media mogul will step off the “Oprah” set in September 2011. He said Winfrey will confirm the news on Friday’s edition of her show. Winfrey notified her staff late Thursday afternoon that she would be ending her talk show on Sept. 9, 2011, just as the show will mark 25 years on the air. The meeting, insiders say, was “emotional, supportive and respectful.” Who will replace Oprah as the new “Queen Of Talk”?

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